- Here is a hypersegmented neutrophil that is present with megaloblastic anemias. There are 8 lobes instead of the usual 3 or 4.
- Such anemias can be due to folate or to B12 deficiency.
- The size of the RBC’s is also increased (macrocytosis, which is hard to appreciate in a blood smear).
- This hypersegmented neutrophil is present along with macro-ovalocytes in a case of pernicious anemia. Compare the size of the RBC’s to the lymphocyte at the lower left center.
Source: http://library.med.utah.edu