Auto-Antibodies

  • Autoantibody is harmful antibody that attacks components of the own body called self antigens.
  • Autoantibodies damage body tissues by phagocytosis (ingestion) or lysis (bursting) of healthy cells
  • Autoantibodies may target single organ such as thyroid gland in Graves’ disease and Hashimoto’s thyroiditis, or maybe systemic and attack several organs.
  • To investigate autoimmune disease we usually check for ANA first (Anti-Nuclear Antibodies) which is positive in many autoimmune diseases but “not specific”.
  • we also check for arthritis and inflammation like CRP + ESR + RF
  • There are big list of autoantibodies and their associated autoimmune diseases like Anti-CCP in “rheumatoid arthritis” or Anti-dsDNA in “SLE”
  • The Photo below is explanation of Grave Disease which is autoimmune disease affect thyroid gland causing excessive release of thyroid hormones —> Hyperthyroidism
  • The Autoantibodies here are directed against TSHR (Throid stimulating hormone receptors)
Grave Disease

Graves Disease


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