Summary of Abnormal Red Blood Cell Morphologies and Disease States
Before we start with the abnormal morphologies, let’s talk about normal morphology of Red Blood Cells.
Normal mature RBC are biconcave, round discs that are about 6 – 8 in ...
NRBCs and Howell Jolly body
A Howell Jolly body is seen in one red cell (A). Also present are two nucleated red blood cells (B).
Nucleated red blood cells (NRBCs): they may look at fist similar to small mature ...
Howell Jolly Bodies
Smooth round dark blue-purple cytoplasmic inclusion
May be centrally located or sometimes in the periphery
Composed of fragments of DNA
Iron stain negative
May Resemble:
Pappenheimer ...
coarse blue granules of Basophilic stippling
Basophilic stippling is the occurrence of fine, medium, or coarse blue granules uniformly distributed throughout some red blood cells.
Fine stippling may be associated with polychromatophilia, ...
basophilic stippling – howel jolley bodies – Cabot Ring – Heinz bodies
A: Basophilic Stippling
B: Howel-Jolley Bodies
C: Cabot’s Ring
E: Heinz Bodies
Basophilic Stippling
the round, dark-blue granules known as basophilic stippling
The granules are composed of precipitated ribosomes and mitochondria in immature red blood cells
Basophilic Stippling ...
