coarse blue granules of Basophilic stippling

  • Basophilic stippling is the occurrence of fine, medium, or coarse blue granules uniformly distributed throughout some red blood cells.
  • Fine stippling may be associated with polychromatophilia, while coarse stippling usually indicates impaired erythropoiesis.
  • Heavy metal poisoning (e.g. lead and arsenic), hemoglobinopathies, thalassemias, sideroblastic anemias, pyrimidine-5’-nucleotidase deficiency, and other diseases should be excluded when coarse basophilic stippling is found.
basophilic stippling

basophilic stippling

 

coarse granules

coarse granules

 

Basophilic stippling and Polychromatophilic erythrocyte

Basophilic stippling and Polychromatophilic erythrocyte

 

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