Blood Plasma and Buffy Coat

Blood Plasma and Buffy Coat

Blood plasma: is prepared by spinning a tube of fresh blood containing an anticoagulant (purple top tube) in a centrifuge until the blood cells fall to the bottom of the tube. The blood ...
Tips for making a good blood smear

Tips for making a good blood smear

<1> Clean slides <2> The size of the drop: not more than 10microL < 3> Speed of spreading action: Don’t move it too slow or too fast to have feathered edge smear. <4> ...
Pappen Heimer Bodies

Pappenheimer bodies VS Howell-Jolly bodies Differentiation

These inclusions are blue-purple in color, irregular in shape and located on the periphery of the cell. They were are Pappenheimer bodies. some people may think these inclusions ...
Howell and Jolly Body - Hairy Cell Leukemia Patient

Howell and Jolly Body from Hair Cell Leukemia Patient

This arrow points to Howell and Jolly body, this blood smear has been taken from 86 old female patient presented with fatigue and abdominal pain, with increased white blood cell ...
sickle cells - Sickle Cell Disease

sickle cell anemia and drepanocytes on smear

a 30 year-old female diagnosed with sickle cell anemia. “Sickle cell anemia (Hb SS disease) is caused by inheritance of two ßs genes and is the most serious of the sickling syndromes. ...
atypical lymphocytes

Infectious mononucleosis and atypical lymphocytosis on a smear

Infectious mononucleosis is an infection usually caused by the Epstein-Barr virus. The virus spreads through saliva, which is why it’s sometimes called “kissing disease.” ...
Trinucleated plasma cell

Trinucleated plasma cell

Trinucleated plasma cell
Crenated Cells

Crenated cells or Burr Cells

Crenated cell have pucker outer edges. Red cells are covered with 10 – 30 short spicules of regular form. (produced in a blood smear which dries slowly, also can be found in uremia, ...
Hyper Segmented Neutrophil

Hypersegmented neutrophil with megaloblastic anemia on smear

Here is a hypersegmented neutrophil that is present with megaloblastic anemias. There are 8 lobes instead of the usual 3 or 4. Such anemias can be due to folate or to B12 deficiency. ...

CBC diagram iron deficiency anemia

This is CBC diagram from patient with iron deficiency anemia, notice that: Hemoglobin, Hematocrit is decreased —> Anemia MCV is low —> Microcytic Anemia MCH is low ...
Sickled RBC's and Nucleated RBC

Aplastic Crisis in a Patient with Sickle Cell Disease

Numerous sickled RBC’s are present (small arrows). A single nucleated RBC is noted (large arrow). Of note is the absence of polychromasia.
Schistocyte - Helmet Cells

schistocytes and helmet cells in a smear accosiated with DIC

There are numerous fragmented RBC’s seen here. Some of the irregular shapes appear as “helmet” cells. Such fragmented RBC’s are known as “schistocytes” ...
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