H-hemoglobin disease
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An inclusion body positive cell seen in Brilliant Cresyl Blue stained red cells of a α0-thalassaemia carrier.
Inclusion Bodies are β4-tetramers precipitating on the red cell membrane, which damages the membrane and induces haemolysis.
HbH is unstable and inclusion body positive cells are more difficult to find in older blood samples.
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Microscopic Features:
Multiple small blue-purple granules distributed within an RBC and visualized with supravital stain
H-hemoglobin disease
