DIC (Disseminated intravascular coagulation)

This is an unusual situation in which there’s a generalised consumption of plasma clotting elements and platelets leading to fibrin deposition throughout the microcirculation. Secondary haemorrhagic occasions are because of the consumption of normal clotting elements and secondary fibrinolysis.

Clinical setting for DIC:

(i) Main trauma
(ii) Septicaemia (usually with acidosis)
(iii) Obstetric crises (placental abruption, eclampsia, retained lifeless foetus)
(iv) Malignancy (acute promyelocytic leukaemia)

Exams for DIC embody FBC (with blood film for fragments), platelet depend (as part of FBC), prothrombin time (PT), APTT, fibrinogen assay and D-dimers.

Pathogenesis of DIC (Disseminated intravascular coagulation)

Pathogenesis of DIC (Disseminated intravascular coagulation)


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