- The acute phase response is a nonspecific response to tissue injury or infection; it affects several organs and tissues. During the acute phase response, there is a characteristic marked increase in the synthesis of some proteins (predominantly in the liver), along with a decrease in the plasma concentration of some others .
- An increase in the synthesis of proteins such as proteinase inhibitors(α1-antitrypsin), coagulation proteins (fibrinogen, prothrombin), complement proteins, and C-reactive protein is of obvious clinical benefit.
- The synthesis of albumin, transthyretin (prealbumin), and transferrin decreases during the acute phase response, and they are thus termed the ‘negative acute phase reactants.
The Acute Phase Response
Reference:
Medical Biochemistry – John W. Baynes, PhD
