The Acute Phase Response

  • The acute phase response is a nonspecific response to tissue injury or infection; it affects several organs and tissues. During the acute phase response, there is a characteristic marked increase in the synthesis of some proteins (predominantly in the liver), along with a decrease in the plasma concentration of some others .
  • An increase in the synthesis of proteins such as proteinase inhibitors(α1-antitrypsin), coagulation proteins (fibrinogen, prothrombin), complement proteins, and C-reactive protein is of obvious clinical benefit.
  • The synthesis of albumin, transthyretin (prealbumin), and transferrin decreases during the acute phase response, and they are thus termed the ‘negative acute phase reactants.
The Acute Phase Response

The Acute Phase Response

Medical Biochemistry – John W. Baynes, PhD


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