Infectious mononucleosis and atypical lymphocytosis on a smear

Infectious mononucleosis is an infection usually caused by the Epstein-Barr virus. The virus spreads through saliva, which is why it’s sometimes called “kissing disease.” occurs most often in teens and young adults. However, you can get it at any age. Symptoms of mono include

  • Fever
  • Sore throat
  • Swollen lymph glands

Sometimes you may also have a swollen spleen. Serious problems are rare.

A blood smear can show Large irregular atypical lymphocytes seen in the peripheral blood of a patient with infectious mononucleosis. The indentation of the cytoplasm of the lymphocyte (arrows) by red blood cells gives rise to the classic “Dutch skirt” appearance of the border

atypical lymphocytes

atypical lymphocytes


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