Pseudo-Thrombocytopenia caused by platelet clumps

Platelet clumps are often discovered when a low automated platelet count is investigated.

The pseudo-thrombocytopenia is commonly the result of the presence of :

  • cold agglutinins
  • EDTA dependent auto-antibodies
  • faulty phlebotomy.

Collecting the specimen in an anticoagulant other than EDTA, such as sodium citrate or acid citrate dextrose, will often resolve the problem.

If collection using these anticoagulants does not resolve the problem, the occurrence may be due to the presence of cold platelet agglutinins and warming the specimen may reverse the clumping.

Platelets Clumps

Platelets Clumps

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