Acid Phosphatase (Prostatic Acid Phosphatase [PAP])

  • Acid phosphatase, also known as prostatic acid phosphatase (PAP), is an enzyme found primarily in the prostate gland, with high concentrations found in the seminal fluid.
  • It is found in smaller concentrations in the kidneys, liver, spleen, bone marrow, erythrocytes, and platelets.
  • Acid phosphatase is used to diagnose advanced metastatic cancer of the prostate and to monitor the patient’s response to therapy.
  • for prostate cancer. In the past, this test has been considered a tumor marker for prostatic cancer. However, with the advent of the prostate-specific antigen (PSA) test, monitoring of the acid phosphatase is decreasing in popularity.
  • An additional use of acid phosphatase testing is testing for its presence in vaginal secretions during the investigation of cases of alleged rape.

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