Jordans Anomaly in White Blood Cells

  • Persistent vacuoles are seen in the protoplasm of granulocytes, monocytes and occasional lymphocytes of some people suffering from ichthyosis or muscular dystrophy or Storage diseases.
  • In the bone marrow these vacuoles were found in the cytoplasm of promyelocytes, myelocytes, metamyelocytes and rarely in plasma cells. They were not observed in blasts or in red cells and thrombocytes and their precursors.
  • With the help of cytochemical staining technics and fluorescence microscopy studies, it was determined that the vacuoles contained lipids
Jordan’s anomaly in peripheral leukocyte

Jordan’s anomaly in peripheral leukocyte

Many vacuoles are seen in the cytoplasm of granulocytes (Jordan’s anomaly)

Many vacuoles are seen in the cytoplasm of granulocytes (Jordan’s anomaly)


Sources:
– bloodjournal.org/content/28/2/258?sso-checked=true

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