- This is a rare chronic lymphoproliferative disorder seen in elderly in which patients have high total leukocyte count along with massive splenomegaly. The prolymphocytes are morphologically characterized by a large nucleus with opened up chromatin and a single centrally placed prominent nucleoli (Figure below).
Prolymphocytes is characterized by medium-sized lymphocytes with prominent nucleoli, larger than B-CLL cells with a moderate amount of pale weakly basophilic cytoplasm,condensed (but more open than in B-CLL) chromatin.it has one round and prominent central nucleolus
- The number of prolymphocytes required for a diagnosis of PLL is 55%.
