- Codocytes (“target cells”) are thin, hypochromatic cells with a round area of central pigmentation.
- Codocytes are characteristically seen after splenectomy, and in patients with thalassemia, and certain hemoglobinopathies (hemoglobin SS, SC, CC, EE, AE, sickle cell-thalassemia).
- They are also found in association with iron deficiency anemia, liver disease, and familial lecithin-cholesterol acyltransferase (LCAT) deficiency.
- If indicated, hemoglobin electrophoresis, liver function evaluation, serum iron studies, serum lipid profile and/or other studies may be indicated.
Target Cell Appearance (Bull’s Eye)
Several Target Cells (Codocytes)
Target Cells
Target Cells (Codocytes) in a smear
Target Cells or Codocytes in patient with Thalassemia
