Codocytes known as Target Cells

  • Codocytes (“target cells”) are thin, hypochromatic cells with a round area of central pigmentation.
  • Codocytes are characteristically seen after splenectomy, and in patients with thalassemia, and certain hemoglobinopathies (hemoglobin SS, SC, CC, EE, AE, sickle cell-thalassemia).
  • They are also found in association with iron deficiency anemia, liver disease, and familial lecithin-cholesterol acyltransferase (LCAT) deficiency.
  • If indicated, hemoglobin electrophoresis, liver function evaluation, serum iron studies, serum lipid profile and/or other studies may be indicated.
Target Cell Appearance (Bull's Eye)

Target Cell Appearance (Bull’s Eye)

Several Target Cells (Codocytes)

Several Target Cells (Codocytes)

Target Cells

Target Cells

Target Cells (Codocytes) in a smear

Target Cells (Codocytes) in a smear

Target Cells or Codocytes in patient with Thalassemia

Target Cells or Codocytes in patient with Thalassemia

 

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