Proteins that transport metal ions

Transferrin transports iron

  • The binding of ferric ions (Fe3+) to transferrin protects against the toxic effects of these ions.
  • In inflammatory reactions, the iron–transferrin complex is degraded by the reticuloendothelial system without a corresponding increase in the synthesis of either of its components; this results in low plasma concentrations of transferrin and iron.


  • It’s the major iron storage protein found in almost all cells of the body.
  • Ferritin acts as the reserve of iron in the liver and bone marrow. The concentration of ferritin in plasma is proportional to the amount of stored iron; therefore measurement of plasma ferritin is one of the best indicators of iron deficiency.
Transferrin and Ferritin

Transferrin and Ferritin


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