Summary of Abnormal Red Blood Cell Morphologies and Disease States
Before we start with the abnormal morphologies, let’s talk about normal morphology of Red Blood Cells.
Normal mature RBC are biconcave, round discs that are about 6 – 8 in ...
Hemoglobin C Diease and Trait laboratory diagnosis
Hemoglobin C (HbC) is an abnormal hemoglobin in which substitution of a glutamic acid with a lysine at the 6th position of the β-globin chain
This mutation is either heterozygous ...
Schistocyte in a case of β- thalassemia intermedia
This smear from a β- thalassemia intermedia patient, the arrow point to a Schistocyte
The Findings:
– Anisocytosis
– Poikilocytosis
– Hypochromia
– Target ...
Codocytes known as Target Cells
Codocytes (“target cells”) are thin, hypochromatic cells with a round area of central pigmentation.
Codocytes are characteristically seen after splenectomy, and in patients ...
Hypochromic microcytic anemia on peripheral smear
This is hypochormic microcytic anemia condition
Hypochormic as central pallor zone increased in most red cells
Microcytic as cells are smaller than normal
Anisocytosis (variation in ...
