Factors known to be promoters of cast formation are:
Increased amount of certain proteins as Albumin, Myoglobin ,and Hemoglobin
Urinary stasis
Cellular debris
Low glomerular filtration ...
Urine sediment showing multiple, muddy brown granular casts. These findings are highly suggestive of acute tubular necrosis in a patient with Acute kidney injury (Acute renal failure).